The MQ binding has some limitations in its use that are listed here.
The publish-subscribe method of distributing messages is not currently supported by the MQ binding though WMQ itself supports publish-subscribe. However, the MQ JMS binding does support this method of distribution.
MQ client connections are the only type of connections supported.
Channel compression, which compresses the data that flows on a WebSphere MQ channel to improve performance, is not supported.
WebSphere MQ headers have specific data types and parsers for them determine the data type of each field in the header. The MQ bindings currently provide support for the MQRFH and MQRFH2 header.