You can use WebSphere MQ links to send a message from one WebSphere Application Server application server to another through a WebSphere MQ network.
Although there are differences between WebSphere Application Server and WebSphere MQ, WebSphere Application Server has the WebSphere MQ link feature, which automatically takes care of most message conversion (of course, data conversion is under your control). A message arriving at a target application server is the same as that leaving the transmitting WebSphere Application Server, despite its conversion from WebSphere Application Server format to WebSphere MQ format and back to WebSphere Application Server format.
Messages with topic style reply-to destinations must have the appropriate publish and subscribe bridge topic mappings defined in the relevant direction in order for reply messages to be transferred between a WebSphere MQ network and WebSphere Application Server. This is not automatic as it is for messages with queue reply destinations.