Try increasing your network socket buffers.
If the high number of RPC retransmits are due to a networked file system, try retuning some of the TCP and UDP parameters.
If possible, choose TCP over UDP as the network transport mechanism for the RPC application.
Check to see if new patches are available for your RPC application. If available, apply these after a suitable system backup. Finally, for networked file systems,
try modifying the filesystem mount options, such as application cache options. Check your man pages for suggestions.
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