If you are operating in a Network Deployment environment it is strongly recommended that you ensure WebSphere Application Server for z/OS synchronizes its configuration after each Administration Console change or Ant target.
When saving the master configuration ensure you manually force synchronization via the Administration Console:
ADMS0208I: The configuration synchronization complete for cell.
Once synchronization is complete, review the server status and various WebSphere Application Server for z/OS logs to ensure success;