Modification of the default digest settings is a relatively straightforward process, but needs to be adequately planned and tested. You will require an application restart for the changes to be implemented and depending on the size and topology of your organization and deployments you need to choose a time when in-progress changes won't be an impact. Also, consider any data (e.g., User passwords) managed by the Cúram Transport Manager (CTM) that will either need to be updated or managed to prevent systems from being out of sync with one another (see the Cúram Transport Manager Guide for more information).
The process is covered in detail in How to Utilize the Superseded Digest Settings for a Period of Migration.
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