You should run egosh ego restart on the master to have configuration changes take effect. However, if you cannot restart your cluster at this time, you can try killing egosc. It will be restarted by vemkd, and the environment variables will take effect.
Note: The service instances that are already started will not be effected by the changes. For changes to apply to all services instances, including those that are already started, run egosh service stop service_name, and then egosh service start service_name.